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http://hdl.handle.net/10872/4890
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| Título : | Dihydroxyacetone Induced Autophagy in African Trypanosomes |
| Autor : | Uzcátegui, Néstor L. |
| Fecha de publicación : | 2007 |
| Editorial : | Landes Bioscience (Autophagy) |
| Citación : | 10 |
| Citación : | 3;6 |
| Resumen : | Dihydroxyacetone (DHA) was examined to explore its trypanocidal activity. The
compound is easily taken up by trypanosomes via its aquaglyceroporins but is not
converted to a glycolytic intermediate due to the lack of a respective kinase. Investigating
the DHA‑induced cell death it became evident that parasites die by autophagy rather than
by necrosis or apoptosis. Since autophagy is not well studied in African trypanosomes
our work offers a way to investigate the importance of autophagy for trypanosomes not
only for stress coping but also for organelle reconstruction during differentiation. |
| URI : | http://hdl.handle.net/10872/4890 |
| ISSN : | 1554-8627 |
| Aparece en las colecciones: | Artículos Publicados
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